Between them the two sides have won five of the previous eight World Cups, with the All Blacks looking to retain their 2015 title in Japan.
The two nations have a fierce, deep-rooted rivalry, and there is little to choose between them – with one draw and a win each from their last three encounters.
New Zealand coach Steven Hansen has opted to play Beauden Barrett at full-back, while Richie Mo’unga comes into fly-half.
Meanwhile South Africa will be looking to inflict the All Blacks’ first Rugby World Cup defeat in 15 matches.
Fans will hope for plenty of fireworks when these two rugby-heavyweights collide in Yokohama.
2019 Rugby World Cup: New Zealand v South Africa
Venue: International Stadium, Yokohama Date: Saturday, 21 September Kick-off: 10:45 BST
Coverage: Full commentary on BBC Radio 5 Live, live text commentary on BBC Sport website and app and live on ITV
Beauden Barrett will start at full-back as New Zealand begin their attempt to win a third straight World Cup against South Africa on Saturday.
Coach Steven Hansen has opted for Crusaders’ Richie Mo’unga at fly-half, with inexperienced wings George Bridge and Sevu Reece also in the XV.
Only five of Barrett’s previous 48 All Black starts have come at 15.
Siya Kolisi leads a South Africa team with a back three of Cheslin Kolbe, Makazole Mapimpi and Willie le Roux.
Gloucester’s Franco Mostert forms the second row with Eben Etzebeth.
Coach Rassie Erasmus said the line-up, which beat Japan 41-7 in their final warm-up, was his “best side”.
New Zealand and South Africa, favourites and second-favourites to win the tournament respectively, have met three times over the past 12 months, each securing narrow victories before July’s 16-16 draw in Wellington.
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Both teams have been preparing for wet and humid conditions in Yokohama, with rain forecast just before kick-off and temperatures expected to be over 20C.
“It’s going to be a massive challenge with the rain they’re predicting. Everyone’s talking about the slippery ball and the wetness. Kicking is going to play a big part,” said Erasmus.
The South Africa coach had suggested earlier in the week that New Zealand’s recent dominance of the international game meant referees gave them preferential treatment.
The All Blacks take on South Africa in a titanic Pool B clash to start their respective Rugby World Cup campaigns in Japan.